Article
Directed molecular evolution by somatic hypermutation.
Protein engineering, design & selection : PEDS - 1 Sept 2004
Wang Clifford L, Yang Desirée C, Wabl Matthias
Abstract excerpt
After rearrangement of immunoglobulin gene segments, the immune system evolves the antibody repertoire by mutating the immunoglobulin variable region at a high rate. While this somatic hypermutation was thought to occur only at the variable region, recent studies suggest that hypermutation can oc...
Topics
- Amino Acid Sequence
- Animals
- B-Lymphocytes
- Base Sequence
- Cell Line, Tumor
- Directed Molecular Evolution
- Genetic Vectors
- Green Fluorescent Proteins
- Mice
- Molecular Sequence Data
- Moloney murine leukemia virus
- Mutagenesis
- Phenotype
- Somatic Hypermutation, Immunoglobulin