Article
Directed molecular evolution by somatic hypermutation.
Protein engineering, design & selection : PEDS - 1 Sept 2004
Wang Clifford L, Yang Desirée C, Wabl Matthias
Abstract excerpt
After rearrangement of immunoglobulin gene segments, the immune system evolves the antibody repertoire by mutating the immunoglobulin variable region at a high rate. While this somatic hypermutation was thought to occur only at the variable region, recent studies suggest that hypermutation can occur at locations throughout the genome. Building upon this notion, we sought to exploit this mechanism as a mutagenesis...
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