Article
Improved methods for detecting selection by mutation analysis of Ig V region sequences.
International immunology - 1 May 2008
Hershberg Uri, Uduman Mohamed, Shlomchik Mark J, Kleinstein Steven H
Abstract excerpt
Statistical methods based on the relative frequency of replacement mutations in B lymphocyte Ig V region sequences have been widely used to detect the forces of selection that shape the B cell repertoire. However, current methods produce an unexpectedly high frequency of false positives and are sensitive to intrinsic biases of somatic hypermutation that can give the appearance of selection. The new statistical...
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