Article
Improved methods for detecting selection by mutation analysis of Ig V region sequences.
International immunology - 1 May 2008
Hershberg Uri, Uduman Mohamed, Shlomchik Mark J, Kleinstein Steven H
Abstract excerpt
Statistical methods based on the relative frequency of replacement mutations in B lymphocyte Ig V region sequences have been widely used to detect the forces of selection that shape the B cell repertoire. However, current methods produce an unexpectedly high frequency of false positives and are s...
Topics
- Animals
- B-Lymphocytes
- DNA Mutational Analysis
- Factor Analysis, Statistical
- Gene Rearrangement, B-Lymphocyte
- Genes, Immunoglobulin
- Immunoglobulin Variable Region
- Lymphoma, Large B-Cell, Diffuse
- Mice
- Mutation
- Sensitivity and Specificity