Article
Novel p21WAF1/CIP1 mutations in superficial and invasive transitional cell carcinomas.
Oncogene - 7 Nov 1996
Malkowicz S B, Tomaszewski J E, Linnenbach A J, Cangiano T A, Maruta Y, McGarvey T W
Abstract excerpt
Alterations in the p53 gene are a predominant component in the development of transitional cell carcinoma (TCC), but the particular pathways distal to p53 alterations which contribute to urothelial transformation are not defined. Here, the p21WAF1/CIP1 gene, a p53 inducible and p53 independent gene product, was studied in TCC. p21WAF1/CIP1 expression was measured by quantitative reverse transcriptase-polymerase...
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