Article
Somatic mutations of the WAF1/CIP1 gene in primary prostate cancer.
Oncogene - 5 Oct 1995
Gao X, Chen Y Q, Wu N, Grignon D J, Sakr W, Porter A T, Honn K V
Abstract excerpt
The WAF1/CIP1 gene, a potential tumor suppressor gene, has recently been cloned and identified as a p53 mediator and an inhibitor for G1 cyclin-dependent kinases (CDKs). We undertook this study to investigate the possible role of the WAF1/CIP1 gene in human prostatic carcinoma. Matched normal and cancer tissues from 18 patients with prostate cancer were screened for WAF1/CIP1 mutation by nested reverse...
Topics
- Base Sequence
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA Primers
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Prostatic Neoplasms