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Article

Somatic mutations of the WAF1/CIP1 gene in primary prostate cancer.

Oncogene - 5 Oct 1995

Gao X, Chen Y Q, Wu N, Grignon D J, Sakr W, Porter A T, Honn K V

Abstract excerpt

The WAF1/CIP1 gene, a potential tumor suppressor gene, has recently been cloned and identified as a p53 mediator and an inhibitor for G1 cyclin-dependent kinases (CDKs). We undertook this study to investigate the possible role of the WAF1/CIP1 gene in human prostatic carcinoma. Matched normal and cancer tissues from 18 patients with prostate cancer were screened for WAF1/CIP1 mutation by nested reverse...

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PMID: 7478562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Somatic mutations of the WAF1/CIP1 gene in primary prostate cancer.PMID 7478562Read ↗

Two variants of the CIP1/WAF1 gene occur together and are associated with human cancer.Semantic proximity Read ↗

Polymorphism of the WAF1 gene is related to susceptibility to cervical cancer in Japanese women.Semantic proximity Read ↗

p21WAF1/CIP1 gene is inactivated in metastatic prostatic cancer cell lines by promoter methylationSemantic proximity Read ↗

Molecular analysis of the Cip1/Waf1 (p21) gene in diverse types of human tumors.Semantic proximity Read ↗

Analysis of p21WAF1/CIP1 in primary bladder tumors.Semantic proximity Read ↗

Association between human cancer and two polymorphisms occurring together in the p21Waf1/Cip1 cyclin-dependent kinase inhibitor geneSemantic proximity Read ↗

Decreased expression and rare somatic mutation of the CIP1/WAF1 gene in human hepatocellular carcinoma.Semantic proximity Read ↗

Absence of WAF1 mutations in a variety of human malignancies.Semantic proximity Read ↗

A somatic mutation of the p21(Waf1/Cip1) gene in a human adrenocortical adenoma.Semantic proximity Read ↗

Mutational analysis of the p21/WAF1/CIP1/SDI1 coding region in human tumor cell lines.Semantic proximity Read ↗

Low levels of expression of an inhibitor of cyclin-dependent kinases (CIP1/WAF1) in primary breast carcinomas with p53 mutations.Semantic proximity Read ↗

Aberrant promoter hypermethylation of p21 (WAF1/CIP1) gene and its impact on expression and role of polymorphism in the risk of breast cancer.Semantic proximity Read ↗

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