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Article

Restoration of preferential and strand specific gene repair in group 2 Chinese hamster ovary mutants (UV5) by the XPD (ERCC2) gene.

Carcinogenesis - 1 Apr 1997

Cullinane C, Weber C A, Dianov G, Bohr V A

Abstract excerpt

It has recently been reported that the XPD (ERCC2) gene is an integral component of the basal transcription factor TFIIH. We have studied the direct role of this repair gene on the fine structure of DNA repair in hamster cells. The gene and strand specific DNA repair of UV induced pyrimidine dimers was determined in wild-type hamster cells, in hamster cells harboring a mutation in the gene homologous to the XPD...

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Source

Identifiers

PMID: 9111200
DOI: 10.1093/carcin/18.4.681

Genes

ERCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Restoration of preferential and strand specific gene repair in group 2 Chinese hamster ovary mutants (UV5) by the XPD (ERCC2) gene.PMID 9111200Read ↗

Common XPD (ERCC2) polymorphisms have no measurable effect on nucleotide excision repair and basal transcription.Semantic proximity Read ↗

The DNA repair genes XPB and XPD defend cells from retroviral infectionSemantic proximity Read ↗

The human DNA repair gene, ERCC2 (XPD), corrects ultraviolet hypersensitivity and ultraviolet hypermutability of a shuttle vector replicated in xeroderma pigmentosum group D cells.Semantic proximity Read ↗

UV radiation-induced XPC translocation within chromatin is mediated by damaged-DNA binding protein, DDB2.Semantic proximity Read ↗

Codominance associated with overexpression of certain XPD mutations.Semantic proximity Read ↗

Functional retroviral vector for gene therapy of xeroderma pigmentosum group D patients.Semantic proximity Read ↗

The formation of UV-induced chromosome aberrations involves ERCC1 and XPF but not other nucleotide excision repair genes.Semantic proximity Read ↗

Persistence of repair proteins at unrepaired DNA damage distinguishes diseases with ERCC2 (XPD) mutations: cancer-prone xeroderma pigmentosum vs. non-cancer-prone trichothiodystrophy.Semantic proximity Read ↗

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Differential processing of UV mimetic and interstrand crosslink damage by XPF cell extracts.Semantic proximity Read ↗

TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.Semantic proximity Read ↗

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