Article
Functional retroviral vector for gene therapy of xeroderma pigmentosum group D patients.
Human gene therapy - 1 Oct 1995
Carreau M, Quilliet X, Eveno E, Salvetti A, Danos O, Heard J M, Mezzina M, Sarasin A
Abstract excerpt
Xeroderma pigmentosum (XP) is an autosomal recessive genetic disorder characterized by an increased frequency of skin cancer following minimal sunlight exposure. Cells isolated from XP patients are also hypersensitive to UV rays and UV-like chemicals. This sensitivity is directly related to a def...
Topics
- Cell Survival
- Cells, Cultured
- Cloning, Molecular
- DNA Helicases
- DNA Repair
- DNA-Binding Proteins
- Fibroblasts
- Gene Transfer Techniques
- Genetic Complementation Test
- Genetic Therapy
- Genetic Vectors
- Humans
- Moloney murine leukemia virus
- Phenotype
- Proteins
- Skin
- Transcription Factors
- Ultraviolet Rays