Article
TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.
The Journal of biological chemistry - 11 Feb 2000
Winkler G S, Araújo S J, Fiedler U, Vermeulen W, Coin F, Egly J M, Hoeijmakers J H, Wood R D, Timmers H T, Weeda G
Abstract excerpt
TFIIH is a multisubunit protein complex involved in RNA polymerase II transcription and nucleotide excision repair, which removes a wide variety of DNA lesions including UV-induced photoproducts. Mutations in the DNA-dependent ATPase/helicase subunits of TFIIH, XPB and XPD, are associated with three inherited syndromes as follows: xeroderma pigmentosum with or without Cockayne syndrome and trichothiodystrophy. By...
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