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Article

Common XPD (ERCC2) polymorphisms have no measurable effect on nucleotide excision repair and basal transcription.

DNA repair - 1 Sept 2007

Lainé Jean Philippe, Mocquet Vincent, Bonfanti Marion, Braun Cathy, Egly Jean Marc, Brousset Pierre

Abstract excerpt

The xeroderma pigmentosum group D (XPD/ERCC2), a subunit of TFIIH, plays a critical role in nucleotide excision repair (NER) and basal transcription. There are hot spots of single nucleotide polymorphism (SNP) within the XPD gene sequence that have been incriminated in the pathophysiology of human cancers, possibly by altering the capacity of the cells for removing DNA damage induced by chemical adducts and UV...

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Identifiers

PMID: 17403617
DOI: 10.1016/j.dnarep.2007.02.010

Genes

ERCC2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Common XPD (ERCC2) polymorphisms have no measurable effect on nucleotide excision repair and basal transcription.PMID 17403617Read ↗

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Every protagonist has a sidekick: Structural aspects of human xeroderma pigmentosum-binding proteins in nucleotide excision repair.Semantic proximity Read ↗

The Structure of the Human ERCC1/XPF Interaction Domains Reveals a Complementary Role for the Two Proteins in Nucleotide Excision RepairSemantic proximity Read ↗

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Strict sun protection results in minimal skin changes in a patient with xeroderma pigmentosum and a novel c.2009delG mutation in XPD (ERCC2).Semantic proximity Read ↗

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