Selective repair of specific chromatin domains in UV-irradiated cells from xeroderma pigmentosum complementation group C.

doi:10.1016/0921-8777(90)90071-c

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Article

Selective repair of specific chromatin domains in UV-irradiated cells from xeroderma pigmentosum complementation group C.

Mutation research - 1 May 1990

Kantor G J, Barsalou L S, Hanawalt P C

Abstract excerpt

The limited DNA-excision repair in UV-irradiated nondividing fibroblasts from xeroderma pigmentosum complementation group C (XP-C) occurs in localized chromatin regions generating large DNA segments (at least 30-70 kb) free of pyrimidine dimers. A genomic fraction enriched for this DNA was isolat...

Topics

Actins
Blotting, Southern
Cells, Cultured
Chromatin
DNA
DNA Repair
Deoxyribonuclease EcoRI
Humans
Mutation
Pyrimidine Dimers
Tetrahydrofolate Dehydrogenase
Transcription, Genetic
Xeroderma Pigmentosum

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