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The DNA repair genes XPB and XPD defend cells from retroviral infection

13 Mar 2006

Abstract excerpt

Reverse transcription of retroviral RNA genomes produce a double-stranded linear cDNA molecule. A host degradation system prevents a majority of the cDNA molecules from completing the obligatory genomic integration necessary for pathogenesis. We demonstrate that the human TFIIH complex proteins XPB (ERCC3) and XPD (ERCC2) play a principal role in the degradation of retroviral cDNA. DNA repair-deficient XPB and...

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PMID: 16537383
DOI: 10.1073/pnas.0509828103

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