Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

UV radiation-induced XPC translocation within chromatin is mediated by damaged-DNA binding protein, DDB2.

Carcinogenesis - 1 Jun 2004

Wang Qi-En, Zhu Qianzheng, Wani Gulzar, Chen Jianming, Wani Altaf A

Abstract excerpt

The tumor suppressor p53 protein has been established as an important factor in modulating the efficiency of global genomic repair. Our recent repair studies in human cells reported that p53 regulates the recruitment of XPC and TFIIH proteins to specific DNA damage sites. Here, we have examined the influence of p53 and damaged-DNA binding complex (DDB2) proteins on the distribution of XPC within damaged chromatin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to Chromatin
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to Mutation

Share to Protein Transport

Share to Tumor Suppressor Protein p53

Share to Ultraviolet Rays

Source

Identifiers

PMID: 14742321
DOI: 10.1093/carcin/bgh085

Genes

XPC
DDB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

UV radiation-induced XPC translocation within chromatin is mediated by damaged-DNA binding protein, DDB2.PMID 14742321Read ↗

Epigenetic remodeling during UV exposure: high resolution analysis of histone post-translational modifications in a DNA binding protein 2 mutant model.Semantic proximity Read ↗

NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites.Semantic proximity Read ↗

p53 Binds and Activates the Xeroderma Pigmentosum <i>DDB2</i> Gene in Humans but Not MiceSemantic proximity Read ↗

DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA.Semantic proximity Read ↗

HMGB1 interacts with XPA to facilitate the processing of DNA interstrand crosslinks in human cells.Semantic proximity Read ↗

The transcription-coupled DNA repair-initiating protein CSB promotes XRCC1 recruitment to oxidative DNA damageSemantic proximity Read ↗

Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair.Semantic proximity Read ↗

Dissection of the molecular defects caused by pathogenic mutations in the DNA repair factor XPC.Semantic proximity Read ↗

Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer.Semantic proximity Read ↗

Epithelial-to-mesenchymal transition and NF-kB pathways are promoted by a mutant form of DDB2, unable to bind PCNA, in UV-damaged human cells.Semantic proximity Read ↗

Generation of DNA single-strand displacement by compromised nucleotide excision repair.Semantic proximity Read ↗

Novel Function of Transcription Factor TTF1 in UV Mediated DNA Damage Repair in Mammalian CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.