Article
Abnormal skeletal patterning in embryos lacking a single Cbp allele: a partial similarity with Rubinstein-Taybi syndrome.
Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 1997
Tanaka Y, Naruse I, Maekawa T, Masuya H, Shiroishi T, Ishii S
Abstract excerpt
CBP is a transcriptional coactivator required by many transcription factors for transactivation. Rubinstein-Taybi syndrome, which is an autosomal dominant syndrome characterized by abnormal pattern formation, has been shown to be associated with mutations in the Cbp gene. Furthermore, Drosophila CBP is required in hedgehog signaling for the expression of decapentapleigic, the Drosophila homologue of bone...
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