Article
UbcD1, a Drosophila ubiquitin-conjugating enzyme required for proper telomere behavior.
Genes & development - 1 Apr 1997
Cenci G, Rawson R B, Belloni G, Castrillon D H, Tudor M, Petrucci R, Goldberg M L, Wasserman S A, Gatti M
Abstract excerpt
The end-to-end association of chromosomes through their telomeres has been observed in normal cells of certain organisms, as well as in senescent and tumor cells. The molecular mechanisms underlying this phenomenon are currently unknown. We show here that five independent mutant alleles in the Drosophila UbcD1 gene cause frequent telomere-telomere attachments during both mitosis and male meiosis that are not seen...
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