Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A role for Brca1 in chromosome end maintenance.

Human molecular genetics - 15 Mar 2006

McPherson J Peter, Hande M Prakash, Poonepalli Anuradha, Lemmers Benedicte, Zablocki Elzbieta, Migon Eva, Shehabeldin Amro, Porras Annaliza, Karaskova Jana, Vukovic Bisera, Squire Jeremy, Hakem Razqallah

Abstract excerpt

The role of BRCA1 in breast and ovarian tumor suppression has been primarily ascribed to the maintenance of genome integrity. BRCA1 interacts with components of the non-homologous end-joining pathway previously shown to play a role in telomere maintenance in yeast. Here, we provide evidence that links Brca1 with telomere integrity. Brca1(-/-) T-cells display telomere dysfunction in both loss of telomere repeats...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to In Situ Hybridization, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins c-bcl-2

Share to T-Lymphocytes

Share to Telomere

Share to Thymoma

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 16446310
DOI: 10.1093/hmg/ddl002

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A role for Brca1 in chromosome end maintenance.PMID 16446310Read ↗

Overview of Roles of Novel Components in the Regulation of DNA Damage Repair in BRCA1-deficient Cancers: An UpdateSemantic proximity Read ↗

BRCA1/2 mutations perturb telomere biology: characterization of structural and functional abnormalities in vitro and in vivo.Semantic proximity Read ↗

The Breast Cancer Susceptibility Gene BRCA2 Is Required for the Maintenance of Telomere HomeostasisSemantic proximity Read ↗

BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution.Semantic proximity Read ↗

The role of BRCA1 in DNA damage response.Semantic proximity Read ↗

Telomere dysfunction in genome instability syndromes.Semantic proximity Read ↗

Molecular functions of BRCA1 in the DNA damage response.Semantic proximity Read ↗

Emerging roles of BRCA1 in transcriptional regulation and DNA repair.Semantic proximity Read ↗

A quantitative assay for telomere protection in Saccharomyces cerevisiae.Semantic proximity Read ↗

Disruption of BRCA1 function results in telomere lengthening and increased anaphase bridge formation in immortalized cell lines.Semantic proximity Read ↗

Understanding the functions of BRCA1 in the DNA-damage response.Semantic proximity Read ↗

The telomere protein Taz1 is required to prevent and repair genomic DNA breaks.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.