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Article

The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability.

Genetics - 1 Jul 2006

Ciapponi Laura, Cenci Giovanni, Gatti Maurizio

Abstract excerpt

The Mre11/Rad50/Nbs (MRN) complex and the two protein kinases ATM and ATR play critical roles in the response to DNA damage and telomere maintenance in mammalian systems. It has been previously shown that mutations in the Drosophila mre11 and rad50 genes cause both telomere fusion and chromosome breakage. Here, we have analyzed the role of the Drosophila nbs gene in telomere protection and the maintenance of...

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Source

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Identifiers

PMID: 16648644
DOI: 10.1534/genetics.106.058081
PMCID: PMC1526684

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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