Article
Correlation of a common mutation in the methylenetetrahydrofolate reductase gene with plasma homocysteine in patients with premature coronary artery disease.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 1997
Christensen B, Frosst P, Lussier-Cacan S, Selhub J, Goyette P, Rosenblatt D S, Genest J, Rozen R
Abstract excerpt
Mild hyperhomocysteinemia, a risk factor for occlusive arterial disease, can be caused by disruptions of homocysteine metabolism. Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, the methyl donor for homocysteine remethylation to methionine. A commo...
Topics
- Adult
- Coronary Disease
- Female
- Homocysteine
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Mutation
- Oxidoreductases Acting on CH-NH Group Donors