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Article

Correlation between C677T MTHFR gene polymorphism, plasma homocysteine levels and the incidence of CAD.

American journal of cardiovascular drugs : drugs, devices, and other interventions - 1 Jan 2001

Nakai K, Itoh C, Nakai K, Habano W, Gurwitz D

Abstract excerpt

The lesions of coronary atherosclerosis represent the result of a complex, multicellular, inflammatory-healing response in the coronary arterial wall. In vivo and in vitro cellular and molecular studies have suggested a role for tissue homocysteine in endothelial cell injury and adverse extra-cellular matrix remodeling. Gene polymorphisms in relation with numerous risk factors might increase the incidence of...

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Source

Identifiers

PMID: 14728017
DOI: 10.2165/00129784-200101050-00005

Genes

CAD
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Correlation between C677T MTHFR gene polymorphism, plasma homocysteine levels and the incidence of CAD.PMID 14728017Read ↗

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