Article
Association of polymorphism in the thermolabile 5, 10-methylene tetrahydrofolate reductase gene and hyperhomocysteinemia with coronary artery disease.
Molecular and cellular biochemistry - 1 Mar 2008
Alam Mohammad A, Husain Syed A, Narang Rajiv, Chauhan Shayam S, Kabra Madhulika, Vasisht Suman
Abstract excerpt
OBJECTIVE: To determine the incidence of methylene tetrahydrofolate reductase (MTHFR) gene 677C-->T polymorphism and plasma homocysteine (Hcy) levels in a group of subjects who underwent coronary angiography, in an attempt to establish a correlation between these parameters and the severity of coronary artery disease (CAD) and to investigate the correlation between hyperhomocysteinemia (HHcy) and the presence of...
Topics
- Coronary Artery Disease
- Enzyme Stability
- Genetic Predisposition to Disease
- Homocysteine
- Humans
- Hyperhomocysteinemia
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Multivariate Analysis
- Phenotype
- Polymorphism, Single Nucleotide
- Regression Analysis