Article
Genetic causes of mild hyperhomocysteinemia in patients with premature occlusive coronary artery diseases.
Atherosclerosis - 1 Mar 1999
Tsai M Y, Welge B G, Hanson N Q, Bignell M K, Vessey J, Schwichtenberg K, Yang F, Bullemer F E, Rasmussen R, Graham K J
Abstract excerpt
Elevated plasma homocysteine is increasingly being recognized as a risk factor for coronary artery disease (CAD). Although there is general agreement on the importance of micronutrients and genetic predisposition to elevated plasma homocysteine, the exact influence of the known prevalent mutations in genes which regulate homocysteine metabolism is not clear. We studied 376 cases of individuals with premature CAD...
Topics
- 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
- Age of Onset
- Coronary Disease
- Cystathionine beta-Synthase
- Fasting
- Female
- Genotype
- Homocysteine
- Humans
- Hyperhomocysteinemia
- Male
- Methionine
- Methylenetetrahydrofolate Reductase (NADPH2)