Article
Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine metabolism and late-onset vascular disease.
Circulation - 15 Dec 1996
Deloughery T G, Evans A, Sadeghi A, McWilliams J, Henner W D, Taylor L M, Press R D
Abstract excerpt
BACKGROUND: Increased homocysteine levels are a risk factor for atherosclerosis and its sequelae. A common genetic mutation in methylenetetrahydrofolate reductase (MTHFR), an enzyme required for efficient homocysteine metabolism, creates a thermolabile enzyme with reduced activity. We determined...
Topics
- Adult
- Age of Onset
- Aged
- Base Sequence
- Blood Donors
- Canada
- DNA Primers
- Gene Frequency
- Genotype
- Homocysteine
- Homozygote
- Humans
- Infant, Newborn
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Oxidoreductases Acting on CH-NH Group Donors
- Point Mutation
- Polymerase Chain Reaction