Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis.

doi:10.1161/01.cir.98.23.2520

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Article

Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis.

Circulation - 8 Dec 1998

Brattström L, Wilcken D E, Ohrvik J, Brudin L

Abstract excerpt

BACKGROUND: The results of retrospective and prospective case-control studies have clearly established that mild elevations of the plasma homocysteine level are associated with increased risk of coronary, cerebral, and peripheral vascular disease. Recently, a mutation (677C-->T) was identified in...

Topics

Cardiovascular Diseases
Humans
Hyperhomocysteinemia
Methylenetetrahydrofolate Reductase (NADPH2)
Mutation
Oxidoreductases Acting on CH-NH Group Donors
Risk Factors

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