Article
Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine and other risk factors for vascular disease.
Atherosclerosis - 1 Aug 1998
Motti C, Gnasso A, Bernardini S, Massoud R, Pastore A, Rampa P, Federici G, Cortese C
Abstract excerpt
A common mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene results in elevated homocysteine levels and, presumably, in increased atherosclerotic risk. We evaluated serum homocysteine levels, MTHFR genotype, and a panel of variables in a sample of 155 middle-aged Italian subjec...
Topics
- Adult
- Female
- Genotype
- Homocysteine
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Mutation
- Oxidoreductases Acting on CH-NH Group Donors
- Regression Analysis
- Risk Factors
- Uric Acid
- Vascular Diseases