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Article

Homocysteine and risk of premature coronary heart disease. Evidence for a common gene mutation.

Circulation - 1 Nov 1996

Gallagher P M, Meleady R, Shields D C, Tan K S, McMaster D, Rozen R, Evans A, Graham I M, Whitehead A S

Abstract excerpt

BACKGROUND: Plasma homocysteine levels are modulated by nutritional and genetic factors, among which is the enzyme methylenetetrahydrofolate reductase (MTHFR). A common defective (thermolabile) variant of this enzyme is causally associated with elevated plasma homocysteine, itself an independent risk factor for coronary heart disease. METHODS AND RESULTS: To examine the hypothesis that the allele (T) that codes...

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Source

Identifiers

PMID: 8901666
DOI: 10.1161/01.cir.94.9.2154

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Homocysteine and risk of premature coronary heart disease. Evidence for a common gene mutation.PMID 8901666Read ↗

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A common mutation in the methylenetetrahydrofolate reductase gene and risk of coronary heart disease: results among U.S. men.Semantic proximity Read ↗

Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and the risk of coronary artery disease.Semantic proximity Read ↗

Association of polymorphism in the thermolabile 5, 10-methylene tetrahydrofolate reductase gene and hyperhomocysteinemia with coronary artery disease.Semantic proximity Read ↗

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