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Article

Thermolabile methylenetetrahydrofolate reductase in coronary artery disease.

Circulation - 21 Oct 1997

Kluijtmans L A, Kastelein J J, Lindemans J, Boers G H, Heil S G, Bruschke A V, Jukema J W, van den Heuvel L P, Trijbels F J, Boerma G J, Verheugt F W, Willems F, Blom H J

Abstract excerpt

BACKGROUND: Hyperhomocysteinemia, an independent and graded risk factor for coronary artery disease (CAD), may result from both environmental and hereditary factors. Methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of methylenetetrahydrofolate to methyltetrahydrofolate, the methyl donor in the remethylation of homocysteine to methionine. A 677C-->T mutation in the MTHFR gene has been...

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Identifiers

PMID: 9355896
DOI: 10.1161/01.cir.96.8.2573

Genes

CAD
MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease.Semantic proximity Read ↗

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