Article
Tumour necrosis factor haplotypes and asthma.
Human molecular genetics - 1 Apr 1997
Moffatt M F, Cookson W O
Abstract excerpt
Airway inflammation is a prominent feature of asthma. The pro-inflammatory cytokine Tumour Necrosis Factor shows constitutional variation in its level of secretion, which is linked to polymorphisms within the TNF gene complex and the surrounding MHC. In this study, 413 subjects in 88 nuclear families from a general population sample were examined for association with asthma and TNF polymorphisms. Ninety-two...
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