Article
Extended tumour necrosis factor/HLA-DR haplotypes and asthma in an Australian population sample.
Thorax - 1 Sept 1999
Moffatt M F, James A, Ryan G, Musk A W, Cookson W O
Abstract excerpt
BACKGROUND: Tumour necrosis factor (TNF) is a potent pro-inflammatory cytokine which is prominent in asthmatic airways. TNF shows genetic variations in secretion which are linked to polymorphisms in the TNF gene complex and the surrounding major histocompatibility (MHC) locus. These polymorphisms do not seem to be themselves functionally important. In these circumstances, the identification of disease associated...
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