Article
Association between - 308 tumour necrosis factor promoter polymorphism and bronchial hyperreactivity in asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Sept 1999
Li Kam Wa T C, Mansur A H, Britton J, Williams G, Pavord I, Richards K, Campbell D A, Morton N, Holgate S T, Morrison J F
Abstract excerpt
BACKGROUND: Tumour necrosis factor (TNF) is a pivotal cytokine in the inflammation underlying asthma. The TNF gene is located in the polymorphic HLA class 3 region on chromosome 6p. Several polymorphisms in this region have been described and associated with alteration of TNF secretion in vitro. OBJECTIVE: In this study we tested the hypothesis that two such polymorphisms, lymphotoxin alpha NcoI B*1 and -308 TNF2...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.