Article
Genetic variation in the TNFA promoter region and TNFA gene expression in subjects with asthma.
The Journal of asthma : official journal of the Association for the Care of Asthma - 1 Aug 2013
Jones Bridgette L, Graham Belinda K, Riffel Amanda K, Dai Hongying, Rosenwasser Lanny J, Vyhlidal Carrie A
Abstract excerpt
OBJECTIVE: Asthma is a chronic disease that affects millions of people. Messenger RNA (mRNA) expression of specific inflammatory markers has been associated with asthma and corticosteroid response. Tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine, has been shown to have increased expression in airways of asthmatics and may be related to corticosteroid sensitivity. The purpose of this study was to...
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