Article
Association of tumor necrosis factor polymorphisms with asthma and serum total IgE.
Human molecular genetics - 15 Feb 2004
Shin Hyoung Doo, Park Byung Lae, Kim Lyoung Hyo, Jung Ji Hyun, Wang Hoe Jin, Kim Young Joo, Park Hae-Sim, Hong Soo-Jong, Choi Byoung Whui, Kim Do-Jin, Park Choon-Sik
Abstract excerpt
Tumor necrosis factors (TNF; TNFA and TNFB) are major pro-inflammatory cytokines that are thought to be important in the pathogenesis of asthma. However, the functions of genetic polymorphisms in these cytokines have not been thoroughly examined in the context of asthma pathology. In an effort to discover polymorphism(s) in genes whose variant(s) have been implicated in asthma phenotypes, we examined the genetic...
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