Article
Association between polymorphism of tumour necrosis factor alpha-308 gene promoter and asthma: a meta-analysis.
Thorax - 1 Jun 2006
Gao J, Shan G, Sun B, Thompson P J, Gao X
Abstract excerpt
BACKGROUND: Asthma is a complex polygenic disease in which gene-environment interactions are important. The gene encoding tumour necrosis factor alpha (TNFalpha) is one of several candidate loci for asthma pathogenesis and is highly polymorphic. A number of studies have investigated the polymorphism of TNFalpha-308 gene promoter (substitution G-->A, designated as TNF1 and TNF2) in relation to asthma...
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