Article
Association of polymorphisms within the tumour necrosis factor (TNF) genes and childhood asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 May 1998
Albuquerque R V, Hayden C M, Palmer L J, Laing I A, Rye P J, Gibson N A, Burton P R, Goldblatt J, Lesouëf P N
Abstract excerpt
BACKGROUND: Tumour necrosis factor alpha (TNFalpha) is a potent modulator of immune and inflammatory responses, and has been implicated in a variety of autoimmune diseases, including asthma. Increased levels of TNFalpha have been detected in both sputa and bronchoalveolar lavage fluid of asthmatic subjects during acute attacks. Interindividual variation in TNFalpha levels may be genetically determined and...
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