Article
Association of polymorphisms within the tumour necrosis factor (TNF) genes and childhood asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 May 1998
Albuquerque R V, Hayden C M, Palmer L J, Laing I A, Rye P J, Gibson N A, Burton P R, Goldblatt J, Lesouëf P N
Abstract excerpt
BACKGROUND: Tumour necrosis factor alpha (TNFalpha) is a potent modulator of immune and inflammatory responses, and has been implicated in a variety of autoimmune diseases, including asthma. Increased levels of TNFalpha have been detected in both sputa and bronchoalveolar lavage fluid of asthmati...
Topics
- Alleles
- Asthma
- Australia
- Case-Control Studies
- Child
- Cohort Studies
- Deoxyribonucleases, Type II Site-Specific
- Gene Frequency
- Genotype
- Humans
- Longitudinal Studies
- Lymphotoxin-alpha
- Polymorphism, Genetic
- Spirometry
- Tumor Necrosis Factor-alpha