Article
TNFA -308G>A in two international population-based cohorts and risk of asthma.
The European respiratory journal - 1 Aug 2008
Castro-Giner F, Kogevinas M, Mächler M, de Cid R, Van Steen K, Imboden M, Schindler C, Berger W, Gonzalez J R, Franklin K A, Janson C, Jarvis D, Omenaas E, Burney P, Rochat T, Estivill X, Antó J M, Wjst M, Probst-Hensch N M
Abstract excerpt
Genetic association studies have related the tumour necrosis factor-alpha gene (TNFA) guanine to adenine substitution of nucleotide -308 (-308G>A) polymorphism to increased risk of asthma, but results are inconsistent. The aim of the present study was to test whether two single-nucleotide polymorphisms, of TNFA and of the lymphotoxin-alpha gene (LTA), are associated with asthma, bronchial hyperresponsiveness and...
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