Article
Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice.
Oncogene - 10 Jul 1997
Andrew S E, Reitmair A H, Fox J, Hsiao L, Francis A, McKinnon M, Mak T W, Jirik F R
Abstract excerpt
Tumors derived from individuals with hereditary nonpolyposis colorectal cancer syndrome frequently demonstrate mutations in both alleles of hMSH2, a key gene in DNA mismatch repair (MMR). Sporadic tumors also frequently exhibit MMR deficiency. In keeping with the role of MMR in the maintenance of genome integrity, mice deficient in MSH2 via gene targeting demonstrate a high incidence of thymic lymphomas and small...
Topics
- Animals
- Base Sequence
- DNA Damage
- DNA Repair
- DNA-Binding Proteins
- Homeodomain Proteins
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- MutS Homolog 2 Protein
- Mutation
- Proto-Oncogene Proteins