Article
Maternal effect for DNA mismatch repair in the mouse.
Genetics - 1 Jan 2002
Gurtu Vanessa E, Verma Shelly, Grossmann Allie H, Liskay R Michael, Skarnes William C, Baker Sean M
Abstract excerpt
DNA mismatch repair (DMR) functions to maintain genome stability. Prokaryotic and eukaryotic cells deficient in DMR show a microsatellite instability (MSI) phenotype characterized by repeat length alterations at microsatellite sequences. Mice deficient in Pms2, a mammalian homolog of bacterial mutL, develop cancer and display MSI in all tissues examined, including the male germ line where a frequency of...
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