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Article

Overexpression of the DNA mismatch repair factor, PMS2, confers hypermutability and DNA damage tolerance.

Cancer letters - 8 Dec 2006

Gibson Shannon L, Narayanan Latha, Hegan Denise Campisi, Buermeyer Andrew B, Liskay R Michael, Glazer Peter M

Abstract excerpt

Inherited defects in genes associated with DNA mismatch repair (MMR) have been linked to familial colorectal cancer. Cells deficient in MMR are genetically unstable and demonstrate a tolerance phenotype in response to certain classes of DNA damage. Some sporadic human cancers also show abnormalities in MMR gene function, typically due to diminished expression of one of the MutL homologs, MLH1. Here, we report...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16426742
DOI: 10.1016/j.canlet.2005.12.009

Genes

PMS2
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Overexpression of the DNA mismatch repair factor, PMS2, confers hypermutability and DNA damage tolerance.PMID 16426742Read ↗

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