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Article

Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair.

Nature genetics - 1 Mar 1998

Prolla T A, Baker S M, Harris A C, Tsao J L, Yao X, Bronner C E, Zheng B, Gordon M, Reneker J, Arnheim N, Shibata D, Bradley A, Liskay R M

Abstract excerpt

Germline mutations in the human MSH2, MLH1, PMS2 and PMS1 DNA mismatch repair (MMR) gene homologues appear to be responsible for most cases of hereditary non-polyposis colorectal cancer (HNPCC; refs 1-5). An important role for DNA replication errors in colorectal tumorigenesis has been suggested by the finding of frequent alterations in the length of specific mononucleotide tracts within genes controlling cell...

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Source

Identifiers

PMID: 9500552
DOI: 10.1038/ng0398-276

Genes

MLH1
PMS1
PMS2
APC
BAX
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair.PMID 9500552Read ↗

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