Article
An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion.
The EMBO journal - 13 Oct 2004
Wen Renren, Chen Yuhong, Schuman James, Fu Guoping, Yang Shoua, Zhang Weiguo, Newman Debra K, Wang Demin
Abstract excerpt
Phospholipase Cgamma1 (PLCgamma1) has been reported to be expressed predominantly in T cells and to play an important role in T-cell receptor signaling. Here we show that PLCgamma1 is expressed throughout B-cell development, with high expression in B-cell progenitors, and is involved in pre-B-cell receptor (pre-BCR) signaling. Reduced expression of PLCgamma1, in the absence of PLCgamma2...
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