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Article

Phospholipase Cγ2 is necessary for separation of blood and lymphatic vasculature in mice

5 Dec 2008

Abstract excerpt

The lymphatic vasculature originates from the blood vasculature through a mechanism relying on Prox1 expression and VEGFC signalling, and is separated and kept separate from the blood vasculature in a Syk- and SLP76-dependent manner. However, the mechanism by which lymphatic vessels are separated from blood vessels is not known. To gain an understanding of the vascular partitioning, we searched for the affected...

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PMID: 19056831
DOI: 10.1242/dev.025353

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