Disruption of the mouse phospholipase C-beta1 gene in a beta-lactoglobulin transgenic line affects viability, growth, and fertility in mice.

doi:10.1016/j.gene.2004.07.007

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Article

Disruption of the mouse phospholipase C-beta1 gene in a beta-lactoglobulin transgenic line affects viability, growth, and fertility in mice.

Gene - 27 Oct 2004

Ballester Maria, Molist Josep, Lopez-Bejar Manel, Sánchez Armand, Santaló Josep, Folch Josep M, Ibáñez Elena

Abstract excerpt

A recessive insertional mutation was identified in one line of transgenic mice for the caprine beta-lactoglobulin (betaLG) gene. High mortality after birth, a significant reduction in postnatal growth and adult body size, changes in the morphometric features of the head, and infertility are the most prominent phenotypic traits of the mutant animals. Molecular cloning and sequencing of the transgene insertion site...

Topics

Animals
Body Weight
Chromosome Mapping
Epilepsy
Female
Fertility
Gene Expression Profiling
Homozygote
In Situ Hybridization, Fluorescence
Isoenzymes
Kidney

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lactoglobulins

Male

Mice

Mice, Inbred Strains

Mice, Transgenic

Mutagenesis, Insertional

Mutation

Source

Open in PubMed

Identifiers

PMID: 15474310
DOI: 10.1016/j.gene.2004.07.007

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