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Article

The Herpesvirus Transactivator VP16 Mimics a Human Basic Domain Leucine Zipper Protein, Luman, in Its Interaction with HCF

1 Aug 1998

Abstract excerpt

In human cells infected with herpes simplex virus (HSV), viral gene expression is initiated by the virion protein VP16. VP16 does not bind DNA directly but forms a multiprotein complex on the viral immediate-early gene promoters with two cellular proteins: the POU domain protein Oct-1 and host cell factor (HCF; also called C1, VCAF, and CFF). Despite its apparent role in stabilizing the VP16-induced transcription...

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Identifiers

PMID: 9658067
DOI: 10.1128/jvi.72.8.6291-6297.1998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Herpesvirus Transactivator VP16 Mimics a Human Basic Domain Leucine Zipper Protein, Luman, in Its Interaction with HCFPMID 9658067Read ↗

Luman, a New Member of the CREB/ATF Family, Binds to Herpes Simplex Virus VP16-Associated Host Cellular FactorSemantic proximity Read ↗

Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16Semantic proximity Read ↗

Host factors associated with either VP16 or VP16‐induced complex differentially affect HSV‐1 lytic infectionSemantic proximity Read ↗

The herpes simplex virus trans-activator VP16 recognizes the Oct-1 homeo domain: evidence for a homeo domain recognition subdomain.Semantic proximity Read ↗

The Neuronal Host Cell Factor-Binding Protein Zhangfei Inhibits Herpes Simplex Virus ReplicationSemantic proximity Read ↗

Amino acid substitutions in the herpes simplex virus transactivator VP16 uncouple direct protein-protein interaction and DNA binding from complex assembly and transactivation.Semantic proximity Read ↗

Potential Role for Luman, the Cellular Homologue of Herpes Simplex Virus VP16 (α Gene <i>trans</i> -Inducing Factor), in Herpesvirus LatencySemantic proximity Read ↗

Protein interactions in the herpes simplex virus type 1 VP16-induced complex: VP16 peptide inhibition and mutational analysis of host cell factor requirements.Semantic proximity Read ↗

Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cells.Semantic proximity Read ↗

HCF-dependent nuclear import of VP16.Semantic proximity Read ↗

The H1 and H2 regions of the activation domain of herpes simplex virion protein 16 stimulate transcription through distinct molecular mechanismsSemantic proximity Read ↗

Transcriptional activation by DNA-binding derivatives of HSV-1 VP16 that lack the carboxyl-terminal acidic activation domain.Semantic proximity Read ↗

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