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Article

Mutational analysis of a transcriptional activation region of the VP16 protein of herpes simplex virus.

Nucleic acids research - 1 Oct 1998

Sullivan S M, Horn P J, Olson V A, Koop A H, Niu W, Ebright R H, Triezenberg S J

Abstract excerpt

The VP16 protein of herpes simplex virus is a potent transcriptional activator of the viral immediate early genes. The transcriptional activation region of VP16 can be divided into two functional subregions, here designated VP16N (comprising amino acids 413-456) and VP16C (amino acids 450-490). A...

Topics

Amino Acid Sequence
Animals
DNA Mutational Analysis
DNA, Viral
Herpes Simplex Virus Protein Vmw65
Molecular Sequence Data
Mutation
Simplexvirus
Transcriptional Activation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9742254
DOI: 10.1093/nar/26.19.4487
PMCID: PMC147869

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9742254-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Mutational analysis of a transcriptional activation region of the VP16 protein of herpes simplex virus.PMID 9742254Read ↗

Critical structural elements of the VP16 transcriptional activation domain.Semantic proximity Read ↗

Defective transcriptional activation by diverse VP16 mutants associated with a common inability to form open promoter complexes.Semantic proximity Read ↗

Transcriptional activation by DNA-binding derivatives of HSV-1 VP16 that lack the carboxyl-terminal acidic activation domain.Semantic proximity Read ↗

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Deletion of the VP16 open reading frame of herpes simplex virus type 1.Semantic proximity Read ↗

Characterization of the interaction between the acidic activation domain of VP16 and the RNA polymerase II initiation factor TFIIB.Semantic proximity Read ↗

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VP16-dependent association of chromatin-modifying coactivators and underrepresentation of histones at immediate-early gene promoters during herpes simplex virus infection.Semantic proximity Read ↗

Protein interactions in the herpes simplex virus type 1 VP16-induced complex: VP16 peptide inhibition and mutational analysis of host cell factor requirements.Semantic proximity Read ↗

Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functionsSemantic proximity Read ↗

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