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Article

Mutational analysis of a transcriptional activation region of the VP16 protein of herpes simplex virus.

Nucleic acids research - 1 Oct 1998

Sullivan S M, Horn P J, Olson V A, Koop A H, Niu W, Ebright R H, Triezenberg S J

Abstract excerpt

The VP16 protein of herpes simplex virus is a potent transcriptional activator of the viral immediate early genes. The transcriptional activation region of VP16 can be divided into two functional subregions, here designated VP16N (comprising amino acids 413-456) and VP16C (amino acids 450-490). Assays of VP16C mutants resulting from both random and alanine-scanning mutagenesis indicated that the sidechains of...

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Identifiers

PMID: 9742254
DOI: 10.1093/nar/26.19.4487
PMCID: PMC147869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutational analysis of a transcriptional activation region of the VP16 protein of herpes simplex virus.PMID 9742254Read ↗

Critical structural elements of the VP16 transcriptional activation domain.Semantic proximity Read ↗

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Phosphorylation of the VP16 transcriptional activator protein during herpes simplex virus infection and mutational analysis of putative phosphorylation sites.Semantic proximity Read ↗

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Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functionsSemantic proximity Read ↗

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