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Host factors associated with either VP16 or VP16‐induced complex differentially affect HSV‐1 lytic infection

7 Sept 2022

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) is an important human pathogen with neurotropism. Following lytic infection in mucosal or skin epithelium, life-long latency is established mainly in sensory neurons, which can periodically reactivate by stress, leading to recurrent disease and virus transmission. During the virus's productive infection, the tegument protein VP16, a component of HSV-1 virion, is physically...

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PMID: 36069169
DOI: 10.1002/rmv.2394

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