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Article

Phosphorylation of the VP16 transcriptional activator protein during herpes simplex virus infection and mutational analysis of putative phosphorylation sites.

Virology - 20 Feb 2006

Ottosen Søren, Herrera Francisco J, Doroghazi James R, Hull Angela, Mittal Sheenu, Lane William S, Triezenberg Steven J

Abstract excerpt

VP16 is a virion phosphoprotein of herpes simplex virus and a transcriptional activator of the viral immediate-early (IE) genes. We identified four novel VP16 phosphorylation sites (Ser18, Ser353, Ser411, and Ser452) at late times in infection but found no evidence of phosphorylation of Ser375, a residue reportedly phosphorylated when VP16 is expressed from a transfected plasmid. A virus carrying a Ser375Ala...

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Identifiers

PMID: 16297954
DOI: 10.1016/j.virol.2005.10.011
PMCID: PMC1717022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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