The HCF repeat is an unusual proteolytic cleavage signal.

doi:10.1101/gad.9.20.2445

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Article

The HCF repeat is an unusual proteolytic cleavage signal.

Genes & development - 15 Oct 1995

Wilson A C, Peterson M G, Herr W

Abstract excerpt

The herpes simplex virus VP16-associated protein HCF is a nuclear host-cell factor that exists as a family of polypeptides encoded by a single gene. The mature HCF polypeptides are amino- and carboxy-terminal fragments of a large approximately 300-kD precursor protein that arise through cleavage...

Topics

Alternative Splicing
Amino Acid Sequence
Base Sequence
Cell Line
HeLa Cells
Herpes Simplex Virus Protein Vmw65
Host Cell Factor C1
Humans
Hydrolysis
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Protein Processing, Post-Translational
Proteins
RNA, Messenger
Recombinant Proteins
Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 7590226
DOI: 10.1101/gad.9.20.2445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7590226-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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