An RNA hairpin at the extreme 5' end of the poliovirus RNA genome modulates viral translation in human cells.

doi:10.1128/JVI.65.2.913-921.1991

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Article

An RNA hairpin at the extreme 5' end of the poliovirus RNA genome modulates viral translation in human cells.

Journal of virology - 1 Feb 1991

Simoes E A, Sarnow P

Abstract excerpt

Several mutations were introduced into an infectious poliovirus cDNA clone by inserting different oligodeoxynucleotide linkers into preexisting DNA restriction endonuclease sites in the viral cDNA. Ten mutated DNAs were constructed whose lesions mapped in the 5' noncoding region or in the capsid coding region of the viral genome. Eight of these mutated cDNAs did not give rise to infectious virus upon transfection...

Topics

Base Sequence
Cell Transformation, Viral
Cloning, Molecular
Genes, Viral
HeLa Cells
Humans
Kinetics
Models, Molecular
Molecular Sequence Data
Mutagenesis, Site-Directed
Nucleic Acid Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Poliovirus

Protein Biosynthesis

RNA, Viral

Transfection

Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 1846205
DOI: 10.1128/JVI.65.2.913-921.1991
PMCID: PMC239832

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1846205-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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