Paternal transmission of the mouse Thp mutation is lethal in some genetic backgrounds.

doi:10.1002/(SICI)1520-6408(1997)20:1<23::AID-DVG3>3.0.CO;2-B

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Article

Paternal transmission of the mouse Thp mutation is lethal in some genetic backgrounds.

Developmental genetics - 1 Jan 1997

Rogers I, Okano K, Varmuza S

Abstract excerpt

Thp is a large deletion on chromosome 17 which includes the maternal lethal gene Tme. Documentation of inheritance patterns suggests that Tme is an imprinted gene which is required for viability; maternal deletion is lethal while paternal deletion is viable. However, paternal transmission of Thp...

Topics

Abnormalities, Multiple
Animals
Chromosome Deletion
Chromosome Mapping
Crosses, Genetic
Edema
Embryonic and Fetal Development
Epistasis, Genetic
Female
Fetal Death
Genes, Lethal
Genomic Imprinting
Genotype
Gestational Age
Male
Mice
Mice, Inbred C3H
Mice, Inbred C57BL

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