Article
Rescue of the T-associated maternal effect in mice carrying null mutations in Igf-2 and Igf2r, two reciprocally imprinted genes.
Development (Cambridge, England) - 1 Jul 1993
Filson A J, Louvi A, Efstratiadis A, Robertson E J
Abstract excerpt
In mice, only the paternal allele of the Igf2 gene, encoding insulin-like growth factor II (IGF-II) is expressed due to parental imprinting. Interestingly, the Igf2r gene, which encodes one of the two known receptors (IGF2R) to which IGF-II binds with high affinity is also subject to imprinting,...
Topics
- Alleles
- Animals
- Base Sequence
- Crosses, Genetic
- Female
- Fetal Death
- Gene Expression Regulation
- Genes
- Genes, Lethal
- Insulin-Like Growth Factor II
- Male
- Mice
- Mice, Inbred C3H
- Mice, Mutant Strains
- Molecular Sequence Data
- Mothers
- Mutation
- Receptor, IGF Type 2