Article
Two doses of the paternal Tme gene do not compensate the lethality of the Thp deletion.
The Journal of heredity - 1 Jan 2000
Agulnik A I, Agulnik S I, Ruvinsky A O
Abstract excerpt
The hairpin-tail (Thp) deletion in chromosome 17 is lethal when it is inherited from the mother, whereas heterozygotes with Thp deletion that is paternal in origin are viable. The lethal effect of maternal Thp is due to a deficiency of the Tme gene that is located in the Thp-deleted region. In this article we describe analysis of the viability of mice with tertiary trisomy of chromosome 17, Ts(17(16]43H, with...
Topics
- Animals
- Chromosome Deletion
- Crosses, Genetic
- Dosage Compensation, Genetic
- Female
- Genes, Lethal
- Male
- Mice
- Mutation
- Tail
- Trisomy