Genetic analysis of genomic imprinting: an Imprintor-1 gene controls inactivation of the paternal copy of the mouse Tme locus.

doi:10.1016/0092-8674(92)90168-c

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Genetic analysis of genomic imprinting: an Imprintor-1 gene controls inactivation of the paternal copy of the mouse Tme locus.

Cell - 7 Aug 1992

Forejt J, Gregorová S

Abstract excerpt

The Thp deletion on mouse chromosome 17 is lethal when inherited from the mother, because it deletes the T-associated maternal effect (Tme) locus, the paternal copy of which is inactivated by genomic imprinting. We have found a paternally nonimprinted Tme variant in crosses of Thp females with Mu...

Topics

Animals
Blotting, Northern
Blotting, Southern
Chromosome Deletion
Female
Fertilization
Gene Expression Regulation
Genes, Dominant
Genes, Lethal
Genetic Variation
Hybridization, Genetic
Insulin-Like Growth Factor II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mannosephosphates

Mice

Mice, Inbred BALB C

Models, Genetic

RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 1322799
DOI: 10.1016/0092-8674(92)90168-c

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1322799-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic analysis of genomic imprinting: an Imprintor-1 gene controls inactivation of the paternal copy of the mouse Tme locus.PMID 1322799Read ↗

Paternal transmission of the mouse Thp mutation is lethal in some genetic backgrounds.Semantic proximity Read ↗

Escape from genomic imprinting at the mouse T-associated maternal effect (Tme) locus.Semantic proximity Read ↗

The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus.Semantic proximity Read ↗

Rescue of the T-associated maternal effect in mice carrying null mutations in Igf-2 and Igf2r, two reciprocally imprinted genes.Semantic proximity Read ↗

Extending the maternal-zygotic effect with genomic imprinting.Semantic proximity Read ↗

IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes.Semantic proximity Read ↗

Tissue-specific and minor inter-individual variation in imprinting of IGF2R is a common feature of Bos taurus Concepti and not correlated with fetal weight.Semantic proximity Read ↗

Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice.Semantic proximity Read ↗

Intraspecific mating with CzechII/Ei mice rescue lethality associated with loss of function mutations of the imprinted genes, Igf2r and Cdkn1c.Semantic proximity Read ↗

Mtr1, a novel biallelically expressed gene in the center of the mouse distal chromosome 7 imprinting cluster, is a member of the Trp gene family.Semantic proximity Read ↗

Inheritance patterns of maternal alleles in imprinted regions of the mouse genome at different stages of development.Semantic proximity Read ↗

Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.