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Article

An allelic series for studying the mouse Thoc1 gene.

Genesis (New York, N.Y. : 2000) - 1 Jan 2007

Wang Xiaoling, Li Yanping, Zhang Xiaojing, Goodrich David W

Abstract excerpt

Thoc1 encodes an essential component of the mammalian TREX protein complex. TREX is an evolutionary conserved complex that couples elongating RNA polymerase II with RNA processing factors. Depletion of Thoc1 protein (pThoc1) compromises transcriptional elongation and nuclear export of some RNAs. Loss of Thoc1 causes periimplantation embryonic lethality in the mouse. Early embryonic lethality precludes analysis of...

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PMID: 17211872
DOI: 10.1002/dvg.20262
PMCID: PMC2799240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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